Nigericin
NALP3 activator
Product Specifications
Background
Nigericin acts as a K and Na ionophore. It stimulates Ca release from mitochondrial stores by disruption of membrane potential.
CAS Number
28643-80-3
Product Name Alternative
(2R) -2-[ (2R,3S,6R) -6-{[ (2S,4R,5R,7R,9R,10R) -2-{ (2S,2'R,3'S,5R,5'R) -5'-[ (2S,3S,5R,6R) -6-Hydroxy-6- (hydroxymethyl) -3,5-dimethyltetrahydro-2H-pyran-2-yl]-2,3'-dimethyloctahydro-2,2'-bifuran-5-yl}-9-metho xy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]dec-7-yl]methyl}-3-methyltetrahydro-2H-pyran-2-yl]propanoic acid
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>98%
Weight
0.05
Format
White to off-white Solid
Solubility
Soluble to 50 mM in DMSO and 20 mM in ethanol
Molecular Formula
C40H67NaO11
Molecular Weight
746.94
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Vercesi A.E., et al. (1993) J Biol Chem. 268: 8564. 2. Graven S.N., Estrada-O, S., Lardy H.A. (1966) Proc Natl Acad Sci USA. 56(2): 654-658.
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