Brefeldin A

GEF inhibitor

Product Specifications

Background

Brefeldin A is a reversible inhibitor of proteins from the endoplasmic reticulum (ER) to the golgi. In mammalian and yeast cells, Brefeldin A targets certain GTP-exchange factosr responsible for activating a GTPase called Arf1p (1, 2).

CAS Number

20350-15-6

Product Name Alternative

Cyanaein

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Cancer | Apoptosis

Purity

>98%

Weight

0.025

Format

White Crystalline Solid

Solubility

Soluble to 10 mM in ethanol and to 50 mM in DMSO

Molecular Formula

C16H24O4

Molecular Weight

280.36

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Klausner R.D., Donaldson J.G., Lippincott-Schwartz J. (1992) J Cell Biol. 116(5): 1071-1080. 2. Nebenfuhr A., Ritzenthaler C., and Robinson D.G. (2002) Plant Physiol. 130(3): 1102-1108.