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R (-) -Gossypol

Bcl-2 inhibitor

Product Specifications

Background

Gossypol is a natural phenol derived from the cotton plant, and is a phenolic aldehyde that permeates cells and acts as an inhibitor for several dehydrogenase enzymes. It has proapoptotic properties, due to the regulation of the Bax and Bcl2. It also reversibly inhibits calcineurin and binds to calmodulin (1, 2).

CAS Number

303-45-7

Product Name Alternative

1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-2,2'-binaphthalene-8,8'-dicarbaldehyde, Gossypol

UNSPSC

41116105

Type

Inducer

Source

Synthetic

Field of Research

Cancer | Apoptosis

Purity

>98%

Weight

0.01

Format

Dark Yellow Solid

Solubility

Soluble to 25 mM in ethanol and in DMSO.

Molecular Formula

C30H30O8

Molecular Weight

518.56

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. www.bioscreening.net “Gossypol” 2. Carruthers N.J., Dowd M.K., and Stemmer P.M. (2007) Eur J Pharmacol. 555(2-3): 106-114.

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