FK506
FKBP inhibitor
Product Specifications
Background
FK506 or Fujimycin or Tacrolimus, is an immunosuppressant. It is mainly used after allogeneic organ transplants, but can also be used topically in the treatment of eczema, uveitis and vitiligo (1). It is a macrolide that prevents the dephosphorylation of NF-AT. It reduces peptidyl-prolyl isomerase activity by binding to FKBP12 creating a new complex that interacts with and inhibits calcineurin (2, 3). It is a neuroprotective in a model of antiretroviral toxic neuropathy (4).
Product Name Alternative
3-(3-Pyridinyl)propyl 1-(3,3-dimethyl-2-oxopentanoyl)prolinate, Tacrolimus, Fujimycin
UNSPSC
41116105
Source
Synthetic
Purity
>98%
Weight
0.01
Format
White powder
Solubility
May be dissolved in DMSO (50 mg/mL) or ethanol (50mg/mL)
Molecular Formula
C44H69HO12
Molecular Weight
804
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Nanette B., et al. (2004) J Am Acad Derm. 51(5): 760-766.
2. Ganong W.F., Review of Medical Physiology (22nd ed.) Lange Medical Books. P.530
3. Liu J. Lane W., Friedman J, Weissman I and Schreiber S. (1991) Cell. 66(4): 807-815 4. Keswani S., et al. (2003) Ann Neurol. 53(1): 57-64.
CAS Number
104987-11-3
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