Necrostatin

Necroptosis inhibitor

Product Specifications

Background

Necrostatin-1 is a specific inhibitor of necroptosis that reduces ischemic tissue damage in stroke models (1). It has also been recently confirmed to be an allosteric RIP1 kinase inhibitor, preotective in NMDa-mediated excitotoxicity and acute pathologies (2,3).

Product Name Alternative

5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone, Necrostatin-1

UNSPSC

41116105

Source

Synthetic

Purity

>98%

Weight

0.05

Format

Light Yellow Solid

Solubility

Soluble to 15 mM in ethanol, and to 30 mM in DMSO

Molecular Formula

C13H13N3OS

Molecular Weight

259.33

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. You Z., et al. (2008) J Cereb Blood Flow Metab. 28(9): 1564-1573. 2. Vandenabeele P., et al. (2010) Nat Rev Mol Cell Biol. 11:700-714. 3. Degterev A., et al. (2008) Nat Chem Biol. 4: 313-321.