Rapamycin

MTOR inhibitor

Product Specifications

Background

Rapamycin or Sirolimus is an immunosuppressant and antifungal. It inhibits the response to interleukin-2, and therefore blocks activation of T and B cells. It binds FKBP12 which then inhibits the mTOR pathway (1). There is also potential treatment for Alzheimer;s, autism and HIV infection (2-3).

CAS Number

53123-88-9

Product Name Alternative

(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R) -1,18-Dihydroxy-12-{1-[ (1S,3R,4R) -4-hydroxy-3-methoxycyclohexyl]-2-propanyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatr icyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene2,3,10,14,20-pentone

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Purity

>98%

Weight

0.005

Format

White Solid

Solubility

Soluble to 100 mM in ethanol, and to 50 mM in DMSO

Molecular Formula

C51H79NO13

Molecular Weight

914.18

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Gruppuso P.A., Boylan J.M., and Sanders J.A. (2011) Cell Cycle. 10(7): EPub. 2. Ehninger D., et al. (2008) Nat. Med. 14(8): 843-848. 3. Donia M., McCubrey J.A., Bendtzen K., and Nicoletti F. (2010) Br J Clin Pharmacol. 70(6): 784-793.