Rapamycin
MTOR inhibitor
Product Specifications
Background
Rapamycin or Sirolimus is an immunosuppressant and antifungal. It inhibits the response to interleukin-2, and therefore blocks activation of T and B cells. It binds FKBP12 which then inhibits the mTOR pathway (1). There is also potential treatment for Alzheimer;s, autism and HIV infection (2-3).
CAS Number
53123-88-9
Product Name Alternative
(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R) -1,18-Dihydroxy-12-{1-[ (1S,3R,4R) -4-hydroxy-3-methoxycyclohexyl]-2-propanyl}-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatr icyclo[30.3.1.04,9]hexatriaconta-16,24,26,28-tetraene2,3,10,14,20-pentone
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | mTOR Inhibitors | Neuroscience | Neurodegeneration | Alzheimer's Disease
Purity
>98%
Weight
0.025
Format
White Solid
Solubility
Soluble to 100 mM in ethanol, and to 50 mM in DMSO
Molecular Formula
C51H79NO13
Molecular Weight
914.18
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Gruppuso P.A., Boylan J.M., and Sanders J.A. (2011) Cell Cycle. 10(7): EPub.
2. Ehninger D., et al. (2008) Nat. Med. 14(8): 843-848.
3. Donia M., McCubrey J.A., Bendtzen K., and Nicoletti F. (2010) Br J Clin Pharmacol. 70(6): 784-793.
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