Forskolin
Adenylate cyclase activator
Product Specifications
Background
Forskolin resensitizes cell receptors by activating adenyl cyclase, and increasing the intracellular levels of cAMP (1). Medically forskolin provides a route to inhibition of colon cancer cell growth and survival (2). It is also a vasodilator, may be helpful in controlling the cause of glaucoma (3), reduces urinary tract infections, and may help to increase the skin's natural resistance to burning under UV light (1).
CAS Number
66575-29-9
Product Name Alternative
(3R,4aR,5S,6S,6aS,10S,10aR,10bS) -6,10,10b-Trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate
UNSPSC
41116105
Type
Activator
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
>99%
Weight
0.05
Format
White Solid
Solubility
Soluble to 100 mM in DMSO, and to 10 mM in ethanol
Molecular Formula
C22H34O7
Molecular Weight
410.51
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Passeron T., Namiki T., Passeron H.J., Le Pape E., and Hearing V.J. (2009) J Invest Dermatol. 129(1): 162-166.
2. McEwan D.G., Brunton V.G., Baillie G.S., Leslie N.R., Houslay M.D., and Frame M.C. (2007) Cancer Research. 67(11).
3. Pescosolido N., and Librando A. (2010) Clin Ter. 161(3): e81-5.
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