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Forskolin

Adenylate cyclase activator

Product Specifications

Background

Forskolin resensitizes cell receptors by activating adenyl cyclase, and increasing the intracellular levels of cAMP (1). Medically forskolin provides a route to inhibition of colon cancer cell growth and survival (2). It is also a vasodilator, may be helpful in controlling the cause of glaucoma (3), reduces urinary tract infections, and may help to increase the skin's natural resistance to burning under UV light (1).

CAS Number

66575-29-9

Product Name Alternative

(3R,4aR,5S,6S,6aS,10S,10aR,10bS) -6,10,10b-Trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-3-vinyldodecahydro-1H-benzo[f]chromen-5-yl acetate

UNSPSC

41116105

Type

Activator

Source

Synthetic

Field of Research

Cancer | Apoptosis

Purity

>99%

Weight

0.05

Format

White Solid

Solubility

Soluble to 100 mM in DMSO, and to 10 mM in ethanol

Molecular Formula

C22H34O7

Molecular Weight

410.51

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Passeron T., Namiki T., Passeron H.J., Le Pape E., and Hearing V.J. (2009) J Invest Dermatol. 129(1): 162-166. 2. McEwan D.G., Brunton V.G., Baillie G.S., Leslie N.R., Houslay M.D., and Frame M.C. (2007) Cancer Research. 67(11). 3. Pescosolido N., and Librando A. (2010) Clin Ter. 161(3): e81-5.

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