Sphingosine
Protein Kinase C inhibitor
Product Specifications
Background
Sphingosine can be phosphorylated in vivo via two kinases which leads to the formation of a potent signaling lipid. It is a selective inhibitor of protein kinase C, but does not inhibit protein kinase A or myosin light chain kinase. It also inhibits calmodulin-dependent enzymes and is the precursor of ceramide.
CAS Number
123-78-4
Product Name Alternative
(2S,3R,4E) -2-Amino-4-octadecene-1,3-diol
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
>98%
Weight
0.1
Format
Solid
Solubility
Soluble to 100 mM in DMSO
Molecular Formula
C18H37NO2
Molecular Weight
299.49
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Radin N. (2003) Biochem J. 371(Pt2): 243-256. 2. Carter H.E., Glick F.J., Norris W.P., Phillips G.E. (1947) J Biol Chem. 170: 285-295.
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