CCT241161
RAF Inhibitor
Product Specifications
Background
CCT241161, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant tumors. It is active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.03µM and 0.01µM for BRAF kinase and SRC kinase respectively.
CAS Number
1163719-91-2
Product Name Alternative
1- (3- (tert-butyl) -1-phenyl-1H-pyrazol-5-yl) -3- (2- (methylthio) -4- ((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl) oxy) phenyl) urea
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
98%
Weight
0.01
Format
White Solid
Solubility
Soluble in DMSO
Molecular Formula
C28H27N7O3S
Molecular Weight
541.63
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.
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