CCT196969
RAF Inhibitor
Product Specifications
Background
CCT196969, a pan-RAF/SFK inhibitor is active against treatment-naive BRAF and NRAS mutant melanoma tumors. It is also active in tumors from patients who developed resistance to BRAF-selective inhibitors and a BRAF plus MEK inhibitor combination. IC50 0.1µM and 0.03µM for BRAF kinase and SRC kinase respectively.
CAS Number
1163719-56-9
Product Name Alternative
1- (3- (tert-butyl) -1-phenyl-1H-pyrazol-5-yl) -3- (2-fluoro-4- ((3-oxo-3,4-dihydropyrido[2,3-b]pyrazin-8-yl) oxy) phenyl) urea, CCT-196969, CCT 196969
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Apoptosis
Purity
96%
Weight
0.01
Format
White Solid
Solubility
Soluble in DMSO
Molecular Formula
C27H24FN7O3
Molecular Weight
513.53
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Girotti, M.R., et al. (2015) Cancer Cell 27.1: 85-96.
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