VU0467154
M4 Receptor Agonist
Product Specifications
Background
Allosteric activators of the M4 muscarinic acetylcholine receptor represent a novel approach for the treatment of psychotic symptoms associated with schizophrenia and other neuropsychiatric disorders. VU0467154 produced a robust dose-dependent reversal of MK-801-induced hyperlocomotion and deficits in preclinical models of associative learning and memory functions in wild-type mice, but failed to reverse these stimulant-induced deficits in M4 KO mice. VU0467154 also enhanced the acquisition of both contextual and cue-mediated fear conditioning when administered alone in wild-type mice.
CAS Number
1451993-15-9
Product Name Alternative
5-amino-3,4-dimethyl-N- (4- ((trifluoromethyl) sulfonyl) benzyl) thieno[2,3-c]pyridazine-6-carboxamide
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Neuroscience| Neurotransmitter Receptors | NMDA Receptors | Neurodegeneration
Purity
>98% (HPLC)
Weight
0.01
Format
Tan Solid
Solubility
Soluble in DMSO
Molecular Formula
C17H15F3N4O3S2
Molecular Weight
444.45
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Bubser M., et. al. (2014) ACS Clinical Neuroscience 5: 920 - 942.
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