NpFR1
Reversible fluorescence intensity-based redox sensor
Product Specifications
Background
NpFR1, or napthalimide-flavin redox sensor 1, is a novel flavin molecule that exhibits a greater than 100-fold increase in fluorescence upon oxidation, and is easily reversible. In the oxidative form, is shows a maximum absorption at 395 and 463nm, max admission at 545nm. Treatment with a mild reducing agent (including sodium thiosulfate, sodium cyanoborohydride, DTT and glutathione) gave the reduced form which exhibited 110-fold lower absorbance, and 125-fold lower emission. Re-oxidation to its original fluorescence can be achieved by air or by hydrogen peroxide.
UNSPSC
41116105
Type
Redox Probe
Source
Synthetic
Field of Research
Cancer | Oxidative Stress
Weight
0.001
Format
Red Solid
Solubility
Soluble in DMSO
Molecular Formula
C23H21N5O4
Molecular Weight
431.45
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Yeow J., Kaur A.K., Anscomb M.D., and New E.J. (2014) Chem. Commun. 50: 8181-8184.
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