115-7C

Hsp70 Activator

Product Specifications

Background

115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02.

Product Name Alternative

4- (5- ((benzyloxy) carbonyl) -4- (2,4-dichlorophenyl) -6-methyl-2-oxo-3,4-dihydropyrimidin-1 (2H) -yl) butanoic acid, SWO2

UNSPSC

41116105

Type

Activator

Source

Synthetic

Field of Research

Cancer | Heat Shock

Purity

>98%

Weight

0.005

Format

White solid

Solubility

Soluble in DMSO (20 mg/ml)

Molecular Formula

C23H22Cl2N2O5

Molecular Weight

477.34

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Wisen et al., (2010) ACS Chem. Biol., 5: 611-622. 2. Jinwal et al. (2009) J.Neurosci. 29:12079. 3. Chafekar et al. (2012) ACS Chem Biol. 7:1556. 4. Walter et al. (2011) J. Biol. Chem. 286:40486