115-7C
Hsp70 Activator
Product Specifications
Background
115-7c activates Hsp70 ATPase turnover rate and promotes Hsp70 substrate refolding. It binds to the IIA subdomain of DnaK and promotes the DnaK-DnaJ complex. Equivalent with SW02.
Product Name Alternative
4- (5- ((benzyloxy) carbonyl) -4- (2,4-dichlorophenyl) -6-methyl-2-oxo-3,4-dihydropyrimidin-1 (2H) -yl) butanoic acid, SWO2
UNSPSC
41116105
Type
Activator
Source
Synthetic
Field of Research
Cancer | Heat Shock
Purity
>98%
Weight
0.005
Format
White solid
Solubility
Soluble in DMSO (20 mg/ml)
Molecular Formula
C23H22Cl2N2O5
Molecular Weight
477.34
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Wisen et al., (2010) ACS Chem. Biol., 5: 611-622.
2. Jinwal et al. (2009) J.Neurosci. 29:12079.
3. Chafekar et al. (2012) ACS Chem Biol. 7:1556.
4. Walter et al. (2011) J. Biol. Chem. 286:40486
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