YM-08
Hsp70 Inhibitor
Product Specifications
Background
YM-08 is a Heat Shock Protein 70 (Hsp70) inhibitor that is blood-brain barrier permeable. YM-08 is a neutral derivative of the Hsp70 inhibitor MKT-077. MKT-077 reduces tau levels in cellular models, but it doesn′t penetrate the blood brain barrier. Although YM-08 was somewhat less effective than MKT-077 in anti-tau and anticancer assays, it selectively reduced pathogenic tau in brain slices, which MKT-077 did not. Furthermore,YM-08 was not retained in the kidney leading one to speculate that it would not have the nephrotoxicity that was a problem for MKT-077 in clinical trials. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
CAS Number
812647-88-4
Product Name Alternative
(2Z,5E) -3-ethyl-5- (3-methyl-1,3-benzothiazol-2-ylidene) -2- (pyridin-2-ylmethylidene) -1,3-thiazolidin-4-one, YM8, YM08
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Heat Shock | Apoptosis | Cell Signaling | Neuroscience | Neurodegeneration | Alzheimer's Disease
Purity
>99% (HPLC)
Weight
0.025
Format
Yellow-orange solid
Solubility
Soluble in DMSO
Molecular Formula
C19H17N3OS2
Molecular Weight
367.49
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Miyata, Y. et al. 2013 ACS Chemical Neuroscience Jun 19;4(6):930-9. doi: 10.1021/cn300210g
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