Herbimycin A
Hsp90 inhibitor
Product Specifications
Background
Herbimycin A, a benzoquinoid ansamycin antibiotic, irreversibly and selectively inhibits tyrosine kinases by reacting with thiol groups (1,2). It is effective on Src, Yes, Fps, Ros, Abl and ErbB oncogene products (1-3) and inhibits thrombin-induced tyrosine phosphorylation of phospholipase C (4). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
CAS Number
70563-58-5
Product Name Alternative
[ (2R,3S,5S,6R,7S,8E,10S,11S,12E,14E) -2,5,6,11-tetramethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1 (21),8,12,14,18-pentaen-10-yl] carbamate
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Heat Shock
Purity
>98%
Weight
0.0001
Format
Yellow Solid
Solubility
Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Molecular Formula
C30H42N2O9
Molecular Weight
574.3
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Uehara Y., and Fukazawa H. (1991) Methods Enzymol. 201: 370.
2. Fukazawa H., et al. (1991) Biochem. Pharmacol. 42: 1661.
3. Satoh T., et al. (1992) J.Biol.Chem. 267: 2537.
4. Weiss R., and Nuccitelli R. (1992) J.Biol.Chem. 267:5608.
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