17-GMB-APA-GA
Hsp90 inhibitor
Product Specifications
Background
An analog of geldanamycin containing a maleimido moiety suitable for preparation of geldanamycin immunoconjugates (1-3). Looking for more information on HSP90? Visit our new HSP90 Scientific Resource Guide at http://www.HSP90.ca.
Product Name Alternative
[ (3R,5S,6R,7S,10S,11S) -21-[3-[4- (2,5-dioxopyrrol-1-yl) butanoylamino]propylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1 (21),8,12,14,18-pentaen-10-yl] carbamate
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Heat Shock
Purity
>98%
Weight
0.001
Format
Purple Solid
Solubility
Soluble in DMSO (>25 mg/ml) and ethanol (10 mg/ml)
Molecular Formula
C39H53N5O11
Molecular Weight
767.9
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Mandler R., et al. (2004) Cancer Res. 64: 1460.
2. Mandler R., et al. (2002) Bioconj. Chem. 13: 786.
3. Mandler R., et al. (2000) J. Natl. Cancer Inst. 92: 1573.
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