What is the catalog number for 17-DMAG?

The catalog number for 17-DMAG is SIH-114A.

What sizes are available for 17-DMAG?

17-DMAG is available in the following size(s): 1 mg.

17-DMAG is currently made to order / not held in immediate stock. Contact us for lead time.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.

What temperature does this product ship at?

Shipping temperature is chosen based on the product’s stability needs, ranging from ambient to dry ice, and is indicated on the product page. Any related shipping fee is shown clearly in your quotation.

What is the molecular weight of the target protein?

Molecular weight information, where applicable, is listed on the datasheet under target details, useful for confirming the correct band on western blot.

17-DMAG

Hsp90 inhibitor

Product Specifications

Background

17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG. It clears alpha-synuclein aggregates by inducton of autophagy (4).

CAS Number

467214-20-6

Product Name Alternative

Alvespimycin, 17DMAG, 17- (dimethylaminoethylamino) -17-demethoxy-geldanamycin, 17- (dimethylaminoethylamino) -17-demethoxygeldanamycin, 17-desmethoxy-17-n, n-dimethylaminoethylamino-geldanamycin, 17-dimethylaminoethylamino-17-demethoxy-geldanamycin, 17-DMAG, 17-Dimethylaminoethylamino, 17-Demethoxygeldanamycin, [ (3R,5S,6R,7S,8E,10S,11S,12Z,14E) -21-[2- (dimethylamino) ethylamino]-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-17-azabicyclo[16.3.1]docosa-1 (21),8,12,14,18-pentaen-10-yl] carbamate

UNSPSC

41116105

Type

Inhibitor

Source

Synthetic

Field of Research

Purity

>98% (TLC) ; NMR conforms

Weight

0.001

Format

Purple Solid

Solubility

Soluble in DMSO (30 mg/ml) and ethanol (10 mg/ml)

Molecular Formula

C32H48N4O8

Molecular Weight

616.8

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Bull E.E., et al.(2004) Clin. Cancer Res. 10: 8077. 2. Gossett D.R. et al.(2005) Gynecol. Oncol. 96: 381. 3. Kaur G. et al.(2004) Clin. Cancer Res. 10: 4813. 4. RA Frake et al. (2015) J Clin Invest. 125(1): 65-74.