N-Acetylgalactosamine BSA Glycoconjugate

N-Acetylgalactosamine (GalNAc) BSA Glycoconjugate is a synthetic glycoprotein mimic used to study O-linked glycosylation in the central nervous system. GalNAc is the initiating sugar in mucin-type O-glycans, which regulate protein stability, trafficking, and cell-cell communication. In the brain, GalNAc-modified proteins are involved in synaptic plasticity, axonal guidance, and neuroimmune interactions. Altered O-glycosylation patterns have been observed in neurodegenerative diseases, including Alzheimer’s and Parkinson’s, where they may influence tau aggregation and neuroinflammation. The GalNAc-BSA conjugate is widely used in ELISA and Western blot assays to detect anti-GalNAc antibodies or lectin binding, supporting research into glycan-based biomarkers and therapeutic targets in neurodegeneration.

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