Pterosin B
Pterosin B is an orally active indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes[1][2][3][4][5].
Product Specifications
CAS Number
34175-96-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Amyloid-β; KLF; Salt-inducible Kinase (SIK)
Type
Natural Products
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Endocrinology; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pterosin-b.html
Purity
99.98
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C1[C@H](C)CC2=C1C(C)=C(CCO)C(C)=C2
Molecular Formula
C14H18O2
Molecular Weight
218.30
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
SIK3
Available Sizes
Frequently Asked Questions
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