Pterosin B

Pterosin B is an orally active indanone. Pterosin B can be obtained from Pteridium aquilinum. Pterosin B is a Sik3 signaling inhibitor. Pterosin B inhibits Klf5 expression and reduces β-amyloid deposition. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice. Pterosin B inhibits cardiomyocyte hypertrophy, improves cognitive impairment, and lowers blood glucose. Pterosin B can be used in research on arthritis, Alzheimer's disease, pathological cardiac hypertrophy and diabetes[1][2][3][4][5].

Product Specifications

CAS Number

[34175-96-7]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; KLF; Salt-inducible Kinase (SIK)

Type

Natural Products

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Endocrinology; Metabolic Disease; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pterosin-b.html

Purity

99.98

Solubility

DMSO : 250 mg/mL (ultrasonic)

Smiles

O=C1[C@H](C)CC2=C1C(C)=C(CCO)C(C)=C2

Molecular Formula

C14H18O2

Molecular Weight

218.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Hannah R.Dexter, et al. A concise stereoselective synthesis of pterosin B. Tetrahedron Letters, Volume 59, Issue 49, 5 December 2018, Pages 4323-4325.|[2]Yahara Y, et al. Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3. Nat Commun. 2016 Mar 24;7:10959.|[3]Lee C Y, et al. Novel therapeutic effects of pterosin B on Ang II-induced cardiomyocyte hypertrophy. Molecules, 2020, 25 (22) : 5279.|[4]Zhang Y, et al. Pterosin B improves cognitive dysfunction by promoting microglia M1/M2 polarization through inhibiting Klf5/Parp14 pathway. Phytomedicine. 2024 Dec;135:156152.|[5]Itoh Y. Pterosin B, ingredient in Pteridium aquilinum, regulates hepatic gluconeogenesis via SIK3-dependent and independent mechanisms. 2017.