Nidufexor
Nidufexor (LMB763) is an orally-available farnesoid X receptor (FXR) agonist for the research of nonalcoholic steatohepatitis (NASH) [1].
Product Specifications
CAS Number
1773489-72-7
Product Name Alternative
LMB763
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; FXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nidufexor.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 83.33 mg/mL (ultrasonic)
Smiles
CN1C(C2=CC(Cl)=CC=C2OC3)=C3C(C(N(CC4=CC=CC=C4)CC5=CC=C(C(O)=O)C=C5)=O)=N1
Molecular Formula
C27H22ClN3O4
Molecular Weight
487.93
Precautions
H302, H315, H319, H335
References & Citations
[1]Chianelli D, et al. Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Apr 23;63 (8) :3868-3880.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
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