Nidufexor

Nidufexor (LMB763) is an orally-available farnesoid X receptor (FXR) agonist for the research of nonalcoholic steatohepatitis (NASH) [1].

Product Specifications

CAS Number

[1773489-72-7]

Product Name Alternative

LMB763

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; FXR

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/nidufexor.html

Concentration

10mM

Purity

99.83

Solubility

DMSO : 83.33 mg/mL (ultrasonic)

Smiles

CN1C(C2=CC(Cl)=CC=C2OC3)=C3C(C(N(CC4=CC=CC=C4)CC5=CC=C(C(O)=O)C=C5)=O)=N1

Molecular Formula

C27H22ClN3O4

Molecular Weight

487.93

Precautions

H302, H315, H319, H335

References & Citations

[1]Chianelli D, et al. Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Apr 23;63 (8) :3868-3880.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Available Sizes

Curated Selection

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