17 (S) -HpDHA
17 (S) -HpDHA is the main 15-Lipoxygenase (LOX) isoenzyme: h15-LOX-1 and h15-LOX-2 and docosahexaenoic acid (DHA) . product. 17 (S) -HpDHA negatively regulates epoxide synthesis via allosteric regulation. 17 (S) -HpDHA also inhibits platelet aggregation with an EC50 of approximately 1 μM[1].
Product Specifications
CAS Number
[123673-33-6]
UNSPSC
12352211
Target
Lipoxygenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/17-s-hpdha.html
Solubility
10 mM in DMSO
Smiles
CC/C=C\C[C@@H](/C=C/C=C\C/C=C\C/C=C\C/C=C\CCC(O)=O)OO
Molecular Formula
C22H32O4
Molecular Weight
360.49
References & Citations
[1]Tsai WC, et al. In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2. Biochemistry. 2021 Jun 8;60 (22) :1741-1754.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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