Human CTSL Protein

<strong>Human CTSL Protein</strong>_x000D_ <strong>Catalog number:</strong> B2012072_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 1 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> Cathepsin L1 isoform 1 protein, CATL protein, CTSL1 protein, MEP protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: You L, Wang Z, Li H, Shou J, Jing Z, Xie J, Sui X, Pan H, Han W. The role of STAT3 in autophagy Autophagy. 2015;11(5):729-39._x000D_ 2: Zhao MM, Yang WL, Yang FY, Zhang L, Huang WJ, Hou W, Fan CF, Jin RH, Feng YM, Wang YC, Yang JK. Cathepsin L plays a key role in SARS-CoV-2 infection in humans and humanized mice and is a promising target for new drug development Signal Transduct Target Ther. 2021 Mar 27;6(1):134._x000D_ 3: Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Nature. 2010 Apr 29;464(7293):1357-61._x000D_ 4: Liszewski MK, Kolev M, Le Friec G, Leung M, Bertram PG, Fara AF, Subias M, Pickering MC, Drouet C, Meri S, Arstila TP, Pekkarinen PT, Ma M, Cope A, Reinheckel T, Rodriguez de Cordoba S, Afzali B, Atkinson JP, Kemper C. Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation Immunity. 2013 Dec 12;39(6):1143-57._x000D_ 5: Lee DH, Park SH, Ahn J, Hong SP, Lee E, Jang YJ, Ha TY, Huh YH, Ha SY, Jeon TI, Jung CH. Mir214-3p and Hnf4a/Hnf4α reciprocally regulate Ulk1 expression and autophagy in nonalcoholic hepatic steatosis Autophagy. 2021 Sep;17(9):2415-2431._x000D_ 6: Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM, Crowley SD, Liu BC. Hydroxychloroquine attenuates renal ischemia/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation Cell Death Dis. 2018 Mar 2;9(3):351._x000D_ 7: Rajput SK, Logsdon DM, Kile B, Engelhorn HJ, Goheen B, Khan S, Swain J, McCormick S, Schoolcraft WB, Yuan Y, Krisher RL. Human eggs, zygotes, and embryos express the receptor angiotensin 1-converting enzyme 2 and transmembrane serine protease 2 protein necessary for severe acute respiratory syndrome coronavirus 2 infection F S Sci. 2021 Feb;2(1):33-42._x000D_ 8: Shibamura-Fujiogi M, Yuki K, Hou L. Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis Int Immunopharmacol. 2021 Apr;93:107425._x000D_ 9: Shi X, Zhang Y. A humanized antibody inhibitor for cathepsin L Protein Sci. 2020 Sep;29(9):1924-1930._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31370861">10: Zhao Y, Shen X, Zhu Y, Wang A, Xiong Y, Wang L, Fei Y, Wang Y, Wang W, Lin F, Liang Z. Cathepsin L-mediated resistance of paclitaxel and cisplatin is mediated by distinct regulatory mechanisms J Exp Clin Cancer Res. 2019 Aug 1;38(1):333. </a>_x000D_ _x000D_ <strong>Products Related to Human CTSL Protein can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>