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ICA

ICA (N- (pyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 μM.

Product Specifications

CAS Number

3374-88-7

Product Name Alternative

N-[4- (2-Pyridinyl) -2-thiazolyl]-2-pyridinamine

UNSPSC

12352005

Target

Parasite

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ICA.html

Purity

99.92

Solubility

DMSO : ≥ 49.5 mg/mL

Smiles

C1(NC2=NC(C3=NC=CC=C3)=CS2)=NC=CC=C1

Molecular Formula

C13H10N4S

Molecular Weight

254.31

References & Citations

[1]Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93.|[2]Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66 (2) :165-76.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Leishmania

Available Sizes

Frequently Asked Questions

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