ICA
ICA (N- (pyridin-2-yl) -4- (pyridin-2-yl) thiazol-2-amine) is a SK channel inhibitor that has antileishmanial activity with an IC50 of 2.1 μM.
Product Specifications
CAS Number
[3374-88-7]
Product Name Alternative
N-[4- (2-Pyridinyl) -2-thiazolyl]-2-pyridinamine
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/ICA.html
Purity
99.92
Solubility
DMSO : ≥ 49.5 mg/mL
Smiles
C1(NC2=NC(C3=NC=CC=C3)=CS2)=NC=CC=C1
Molecular Formula
C13H10N4S
Molecular Weight
254.31
References & Citations
[1]Bhuniya D, et al. Aminothiazoles: Hit to lead development to identify antileishmanial agents. Eur J Med Chem. 2015 Sep 18;102:582-93.|[2]Skibsbye L, et al. Antiarrhythmic Mechanisms of SK Channel Inhibition in the Rat Atrium. J Cardiovasc Pharmacol. 2015 Aug;66 (2) :165-76.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Leishmania
Available Sizes
Curated Selection
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