DPPE-PEG2000 (ammonium)

DPPE-PEG2000 ammonium (16:0 PEG2000 PE ammonium) is a PEG-modified lipids. DPPE-PEG2000 can reduce the nonspecific adsorption of protein and prolong circulation time in vivo. DPPE-PEG2000 can be used in liposome preparation. DPPE-PEG2000 is also used in preparation of tripeptide arginine-glycine-aspartic acid magnetoliposomes and poly (ethylene glycol) (PEG) – MLPs[1][2][3].

Product Specifications

CAS Number

[474922-84-4]

Product Name Alternative

16:0 PEG2000 PE (ammonium) ; 1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy (polyethylene glycol) -2000] (ammonium)

UNSPSC

12352200

Target

Liposome

Type

Biochemical Assay Reagents

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/16-0-peg2000-pe.html

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCCOP(O)(OC[C@@H](COC(CCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCC)=O)=O)OCCOC.N.[n]

Molecular Formula

(C2H4O) nC39H76NO10P.H3N

Molecular Weight

2700 (Average)

References & Citations

[1]Xiao H, et al. Regulation of microglia polarization via mannose receptor-mediated delivery of siRNA by ligand-functionalized DoGo LNP. RSC Adv. 2021 Oct 4;11 (52) :32549-32558.|[2]Estelrich J, et al., Effect of PEGylation on Ligand-Targeted Magnetoliposomes: A Missed Goal. ACS Omega. 2017 Oct 31;2 (10) :6544-6555.|[3]Wolfram J, et al., Shrinkage of pegylated and non-pegylated liposomes in serum. Colloids Surf B Biointerfaces. 2014 Feb 1;114:294-300.