NDR1 Antibody (pSer281+pThr282)

NDR1 (Nuclear Dbf2-related kinase 1), a member of the AGC family of serine/threonine kinases, plays a pivotal role in cell cycle regulation, apoptosis, and neuronal development. Phosphorylation at Ser281 and Thr282 is essential for its activation and downstream signaling. In the nervous system, NDR1 influences dendritic arborization, synaptic plasticity, and neuronal survival. Activated NDR1 modulates the Hippo signaling pathway and interacts with upstream kinases such as MST1/2, integrating extracellular stress signals with intracellular responses. In neurodegenerative disease, dysregulation of NDR1 phosphorylation may impair neuronal architecture and promote apoptotic pathways. Its role in cytoskeletal remodeling and axonal transport positions NDR1 as a key regulator of neuronal integrity. Recent studies suggest that aberrant NDR1 activity contributes to neuroinflammation and glial dysfunction, both of which are central to the progression of diseases like Alzheimer’s and ALS. The dual phosphorylation at Ser281 and Thr282 enhances NDR1’s catalytic activity, making these sites potential biomarkers for kinase-driven neurodegenerative processes. Targeting NDR1 phosphorylation dynamics may offer therapeutic strategies to preserve neuronal structure and function in degenerative conditions.

NDR1, NDR, STK38, STK 38, STK38_HUMAN, Nuclear Dbf2-related kinase 1, NDR1 protein kinase, Ndr Ser/Thr kinase-like protein, Serine/threonine protein kinase 38

A 1:250 dilution of SPC-1035 was sufficient for detection of NDR1 (pSer281+pThr282) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.