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SMIP-031

SMIP-031 is a potent and orally active PPM1A inhibitor with an IC50 value of 180 nM. SMIP-031 induces autophagy. SMIP-031 inhibits Mycobacterium tuberculosis infect in mice[1].

Product Specifications

UNSPSC

12352005

Target

Autophagy; Phosphatase

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/smip-031.html

Smiles

OCC[N+]1=CC2=C(C=CC(OCC)=C2)C3=CC(F)=CC=C31.[Br-]

Molecular Formula

C17H17BrFNO2

Molecular Weight

366.22

References & Citations

[1]Yu Z, et al. Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy. J Med Chem. 2024 Jul 3.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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