SMIP-031
SMIP-031 is a potent and orally active PPM1A inhibitor with an IC50 value of 180 nM. SMIP-031 induces autophagy. SMIP-031 inhibits Mycobacterium tuberculosis infect in mice[1].
Product Specifications
UNSPSC
12352005
Target
Autophagy; Phosphatase
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/smip-031.html
Smiles
OCC[N+]1=CC2=C(C=CC(OCC)=C2)C3=CC(F)=CC=C31.[Br-]
Molecular Formula
C17H17BrFNO2
Molecular Weight
366.22
References & Citations
[1]Yu Z, et al. Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy. J Med Chem. 2024 Jul 3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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