N- (p-Tosyl) -GPR-pNA (acetate)

N- (p-Tosyl) -GPR-pNA acetate (Chromozym-TH) is a chromogenic substrate targeting the synthetic peptides Hirunorm IV and Hirunorm V and can be used to detect the dissociation constants (KI) of both peptides. Hirunorm IV and Hirunorm V are reversible inhibitors of amidolytic thrombin activity. By varying the peptide concentration at a fixed concentration of the chromogenic substrate N- (p-Tosyl) -GPR-pNA acetate, the dissociation constants determined were 0.134 nM (Hirunorm IV) and 0.245 nM (Hirunorm V) [1].

Product Specifications

CAS Number

[86890-95-1]

Product Name Alternative

Chromozym-TH

UNSPSC

12171500

Target

Fluorescent Dye

Type

Dye Reagents

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-p-tosyl-gpr-pna-acetate.html

Purity

99.9

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C([C@H](CCC1)N1C(CN[S](=O)(C(C=C2)=CC=C2C)=O)=O)N[C@@H](CCCNC(N)=N)C(NC(C=C3)=CC=C3[N](=O)=O)=O.CC(O)=O

Molecular Formula

C28H38N8O9S

Molecular Weight

662.71

References & Citations

[1]Cappiello M, et al. Kinetics of human thrombin inhibition by two novel peptide inhibitors (Hirunorm IV and Hirunorm V) . Biochem Pharmacol. 1996 Oct 25;52 (8) :1141-6.