G6PD Antibody (pTyr401)

Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway, responsible for generating NADPH—an essential cofactor for antioxidant defense and redox homeostasis in neurons. The phosphorylation of G6PD at tyrosine 401 (pTyr401) represents a critical post-translational modification that enhances its enzymatic activity and regulatory potential under oxidative stress conditions. In the context of neurodegenerative diseases, such as Alzheimer’s, Parkinson’s, and ALS, oxidative damage and impaired redox balance are central pathological features. G6PD (pTyr401) plays a neuroprotective role by boosting NADPH production, thereby supporting glutathione recycling and mitigating reactive oxygen species (ROS) -induced neuronal injury. Dysregulation of this phosphorylation event may compromise cellular resilience, leading to increased vulnerability of neurons to metabolic and oxidative insults. Emerging evidence suggests that G6PD (pTyr401) may also influence neuroinflammatory signaling and mitochondrial function—two processes intricately linked to disease progression. Its dynamic regulation in response to cellular stress positions G6PD (pTyr401) as a promising biomarker for early detection and a potential target for therapeutic intervention in neurodegeneration. As interest grows in redox biology and metabolic reprogramming in the brain, G6PD (pTyr401) offers a compelling link between metabolic adaptation and neuronal survival.

Cardiovascular System | Atherosclerosis | Diabetes Associated | Cardiovascular System | Heart | Cardiac Metabolism | Cancer | Cancer Metabolism | Cancer Carbohydrate Metabolism | Cell Signaling | Metabolism | Diabetes

A 1:250 dilution of SPC-986 was sufficient for detection of G6PD (pTyr401) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.