CDK10 Antibody (pThr196) : ATTO 488

Rabbit Anti-Human CDK10 (pThr196) Polyclonal

Product Specifications

Background

CDK10 is a serine/threonine kinase involved in regulating the G2-M phase of the cell cycle. Although historically studied in the context of cellular proliferation, recent evidence suggests CDK10 may also influence neuronal differentiation, cytoskeletal dynamics, and transcriptional regulation. Phosphorylation at threonine 196 (pThr196) is critical for CDK10 activation and function. In neurons, dysregulation of CDK10 activity may disrupt cell cycle re-entry, a pathological hallmark observed in several neurodegenerative diseases, including Alzheimer’s disease. As a modulator of both cell cycle and transcriptional machinery, CDK10 represents a novel candidate for investigating the molecular underpinnings of neurodegeneration.

CAS Number

9007-83-4

Specifications

Detects 41.038 kDa.

Product Name Alternative

CDK10, Cyclin-dependent kinase 10, Cell division protein kinase 10, CDC2-related protein kinase, CDK10_HUMAN, PISSLRE, Serine/threonine protein kinase PISSLRE

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

8558

Swiss Prot

Q15131

Accession Number

NP_443714

Cellular Locus

Cytoplasmic

Host

Rabbit

Species Reactivity

Human

Immunogen

A phospho-specific peptide corresponding to residues surrounding Thr196 of human CDK10 (AA193-199)

Target

CDK10 (pThr196)

Clonality

Polyclonal

Conjugation

ATTO 488

Type

Polyclonal

Applications

WB | AM

Validated Applications

IHC,ICC/IF

Field of Research

Purification

Peptide Affinity Purified

Detection Range

A 1:250 dilution of SPC-939 was sufficient for detection of CDK10 (pThr196) in 10 µg of HeLa cell lysate by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.