Rho-Kinase-IN-2
Product Specifications
UNSPSC Description
Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS)-penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM). Rho-Kinase-IN-2 can be used in Huntington’s research[1].
Target Antigen
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Stem Cell/Wnt;TGF-beta/Smad
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rho-kinase-in-2.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1[C@H](C)CN(C2=C(F)C=NC=C2)CC1)N[C@@H](C3=CC=CC(OC)=C3)C
Molecular Weight
372.44
References & Citations
[1]Tammy Ladduwahetty, et al. Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease. J Med Chem. 2022 Jul 11.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-150640/Rho-Kinase-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-150640/Rho-Kinase-IN-2-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2573071-18-6
Available Sizes
Curated Selection
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