Rho-Kinase-IN-2

Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS) -penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM) . Rho-Kinase-IN-2 can be used in Huntington’s research[1].

Product Specifications

CAS Number

[2573071-18-6]

UNSPSC

12352005

Target

ROCK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/rho-kinase-in-2.html

Concentration

10mM

Purity

98.80

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N1[C@H](C)CN(C2=C(F)C=NC=C2)CC1)N[C@@H](C3=CC=CC(OC)=C3)C

Molecular Formula

C20H25FN4O2

Molecular Weight

372.44

References & Citations

[1]Tammy Ladduwahetty, et al. Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease. J Med Chem. 2022 Jul 11.