Rho-Kinase-IN-2
Rho-Kinase-IN-2 (Compound 23) is an orally active, selective, and central nervous system (CNS) -penetrant Rho Kinase (ROCK) inhibitor (ROCK2 IC50=3 nM) . Rho-Kinase-IN-2 can be used in Huntington’s research[1].
Product Specifications
CAS Number
[2573071-18-6]
UNSPSC
12352005
Target
ROCK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/rho-kinase-in-2.html
Concentration
10mM
Purity
98.80
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(N1[C@H](C)CN(C2=C(F)C=NC=C2)CC1)N[C@@H](C3=CC=CC(OC)=C3)C
Molecular Formula
C20H25FN4O2
Molecular Weight
372.44
References & Citations
[1]Tammy Ladduwahetty, et al. Identification of a Potent, Selective, and Brain-Penetrant Rho Kinase Inhibitor and its Activity in a Mouse Model of Huntington's Disease. J Med Chem. 2022 Jul 11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ROCK2
Available Sizes
Curated Selection
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