Pitavastatin lactone
Pitavastatin lactone is a major metabolite of Pitavastatin in humans. Pitavastatin is a potent competitive inhibitor of HMG-CoA reductase little metabolized in hepatic microsomes[1].
Product Specifications
CAS Number
[141750-63-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319
Target
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pitavastatin-lactone.html
Purity
98.09
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C[C@H](O)C[C@@H](/C=C/C2=C(C3=CC=C(F)C=C3)C4=CC=CC=C4N=C2C5CC5)O1
Molecular Formula
C25H22FNO3
Molecular Weight
403.45
Precautions
H302, H315, H319
References & Citations
[1]Fujino H, et al. Metabolic fate of pitavastatin, a new inhibitor of HMG-CoA reductase: human UDP-glucuronosyltransferase enzymes involved in lactonization. Xenobiotica. 2003 Jan;33 (1) :27-41.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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