BubR1 Antibody (pSer670): ATTO 488

Rabbit Anti-Human BubR1 (pSer670) Polyclonal

Product Specifications

Background

BUBR1 is a protein-serine/threonine kinase. It is an essential component of mitotic checkpoint. It prevents progression of anaphase until all the sister chomatids are connected to spindles by binding to CDC20 to anaphase promoting complex/cycolsome thus inhibiting it. It is also involved in localization of CENPE, a kinetochore motor that performs kinetochore functions. Other functions include suppression of centrosome amplification, negative regulation of PLK1 in intephase and trigger apoptosis in polyploid cells.

CAS Number

9007-83-4

Specifications

Detects 119 kDa.

Product Name Alternative

Cancer, Cell Cycle, Cell Division, Cell Signaling, Epigenetics and Nuclear Signaling, Cell Signaling, Protein Phosphorylation

Gene ID

701

Swiss Prot

O60566

Accession Number

NP_001202

Cellular Locus

Cytoplasm | Nucleus

Host

Rabbit

Species Reactivity

Human

Immunogen

A phospho-specific peptide corresponding to residues surrounding Ser670 of human BUBR1 (AA667-673)

Target

BubR1 (pSer670)

Clonality

Polyclonal

Conjugation

ATTO 488

Tissue Specificity

Highly expressed in thymus followed by spleen. Preferentially expressed in tissues with a high mitotic index.

Validated Applications

IHC,ICC/IF

Purification

Peptide Affinity Purified

Dilution

WB (1:250); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Documents

Product Datasheet

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Product MSDS

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