BRSK1 Antibody (pThr189): FITC
Rabbit Anti-Human BRSK1 (pThr189) Polyclonal
Product Specifications
Background
BRSK1 (BR serine/threonine-protein kinase 1), also known as SAD1, is a 794 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one UBA domain and one protein kinase domain. Expressed in a variety of tissues with highest expression in testis and brain, BRSK1 uses magensium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins, including Wee 1 and Cdc25B. Via its kinase activity toward proteins that are involved in microtubule assembly, BRSK1 plays an essential role in neuronal polarization and may be involved in regulating cell cycle arrest in response to DNA damage, Two isoforms of BRSK1 exist due to alternative splicing events.
CAS Number
9007-83-4
Specifications
Detects 86.753 kDa.
Product Name Alternative
Cancer, Cell Cycle, Cell Signaling, Protein Phosphorylation
Gene ID
84446
Swiss Prot
Q8TDC3
Accession Number
NP_115806
Cellular Locus
Cytoplasm | Nucleus
Host
Rabbit
Species Reactivity
Human
Immunogen
A phospho-specific peptide corresponding to residues surrounding Thr189 of human BRSK1 (AA186-192)
Target
BRSK1 (pThr189)
Clonality
Polyclonal
Conjugation
FITC
Validated Applications
IHC,ICC/IF
Purification
Peptide Affinity Purified
Dilution
WB (1:250); optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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