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BRSK1 Antibody (pThr189): ATTO 488

Rabbit Anti-Human BRSK1 (pThr189) Polyclonal

Product Specifications

Background

BRSK1 (BR serine/threonine-protein kinase 1), also known as SAD1, is a 794 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one UBA domain and one protein kinase domain. Expressed in a variety of tissues with highest expression in testis and brain, BRSK1 uses magensium as a cofactor to catalyze the ATP-dependent phosphorylation of target proteins, including Wee 1 and Cdc25B. Via its kinase activity toward proteins that are involved in microtubule assembly, BRSK1 plays an essential role in neuronal polarization and may be involved in regulating cell cycle arrest in response to DNA damage, Two isoforms of BRSK1 exist due to alternative splicing events.

Specifications

Detects 86.753 kDa.

Product Name Alternative

Cancer, Cell Cycle, Cell Signaling, Protein Phosphorylation

Gene ID

84446

Swiss Prot

Q8TDC3

Accession Number

NP_115806

Cellular Locus

Cytoplasm | Nucleus

Host

Rabbit

Species Reactivity

Human

Immunogen

A phospho-specific peptide corresponding to residues surrounding Thr189 of human BRSK1 (AA186-192)

Target

BRSK1 (pThr189)

Clonality

Polyclonal

Conjugation

ATTO 488

Validated Applications

IHC,ICC/IF

Purification

Peptide Affinity Purified

Dilution

WB (1:250); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36mM Ethanolamine, and 9.09mM Sodium Bicarbonate in 90.9% PBS

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Product Datasheet

https://cdn.gentaur.com/products/400/4419059/datasheet/spc-927d-a488.pdf

Product MSDS

https://cdn.gentaur.com/products/400/4419059/msds/spc-927d-a488.pdf

CAS Number

9007-83-4

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