CWI1-2 (hydrochloride)

CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1].

Product Specifications

CAS Number

[2408590-37-2]

UNSPSC

12352005

Hazard Statement

H314

Target

Apoptosis

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cwi1-2-hydrochloride.html

Purity

98.27

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

OC(C=C1)=C(C=C1Cl)/C=N/N=C(N/N=C\C(C=C2Cl)=C(C=C2)O)\N/N=C/C(C=C3Cl)=C(C=C3)O.[H]Cl

Molecular Formula

C22H18Cl4N6O3

Molecular Weight

556.23

Precautions

H314

References & Citations

[1]Hengyou Weng, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40 (12) :1566-1582.e10.