CWI1-2 (hydrochloride)
CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1].
Product Specifications
CAS Number
[2408590-37-2]
UNSPSC
12352005
Hazard Statement
H314
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cwi1-2-hydrochloride.html
Purity
98.27
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(C=C1)=C(C=C1Cl)/C=N/N=C(N/N=C\C(C=C2Cl)=C(C=C2)O)\N/N=C/C(C=C3Cl)=C(C=C3)O.[H]Cl
Molecular Formula
C22H18Cl4N6O3
Molecular Weight
556.23
Precautions
H314
References & Citations
[1]Hengyou Weng, et al. The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia. Cancer Cell. 2022 Dec 12;40 (12) :1566-1582.e10.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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