Aurantiamide acetate

Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2].

Product Specifications

CAS Number

[56121-42-7]

Product Name Alternative

Asperglaucide

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Cathepsin

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/aurantiamide-acetate.html

Purity

99.85

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C(N[C@H](COC(C)=O)CC1=CC=CC=C1)[C@@H](NC(C2=CC=CC=C2)=O)CC3=CC=CC=C3

Molecular Formula

C27H28N2O4

Molecular Weight

444.52

Precautions

H302, H315, H319, H335

References & Citations

[1]K Isshiki, et al. Aurantiamide Acetate, a Selective Cathepsin Inhibitor, Produced by Aspergillus Penicilloides. Biosci Biotechnol Biochem. 2001 May;65 (5) :1195-7.|[2]Chi-Su Yoon, et al. Anti-neuroinflammatory Effect of Aurantiamide Acetate From the Marine Fungus Aspergillus Sp. SF-5921: Inhibition of NF-κB and MAPK Pathways in Lipopolysaccharide-Induced Mouse BV2 Microglial Cells.Int Immunopharmacol. 2014 Dec;23 (2) :568-74.