MDM2 Antibody: ATTO 594

Rabbit Anti-Human MDM2 Polyclonal

Product Specifications

Background

MDM2 (Mouse Double Minute 2 homolog) is an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53, controlling its stability and transcriptional activity. In the nervous system, MDM2-p53 signaling is crucial for balancing neuronal survival and apoptosis. Overactivation of p53, due to MDM2 dysfunction, can lead to excessive neuronal loss—a feature observed in neurodegenerative diseases such as Parkinson’s and ALS. MDM2 also influences synaptic plasticity and neurogenesis, suggesting broader roles in cognitive function and brain repair. Targeting the MDM2-p53 axis offers a potential neuroprotective strategy by modulating stress responses and preventing p53-mediated neurotoxicity in degenerative conditions.

CAS Number

9007-83-4

Specifications

Detects ~50 kDa. ~50 kDa band is isoform 2 or 3.

Product Name Alternative

MDM2, Double minute 2 protein, Hdm2, MTBP, Mouse Double Minute 2, HDMX, ACTFS, p53 Binding Protein Mdm2, Ubiquitin protein ligase E3 Mdm2, Mdm2 p53 E3 ubiquitin protein ligase homolog, MDM2BP, p53-binding protein Mdm2, Oncoprotein Mdm2, Hdm 2, E3 ubiquitin-protein ligase Mdm2, MDM 2, EC:6.3.2.-, MDM2_HUMAN, MDM2 oncogene E3 ubiquitin protein ligase, Murine Double Minute Chromosome 2, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa

UNSPSC

12352203

UN Code

Non-hazardous

Hazard Statement

Non-hazardous

Gene ID

4193

Swiss Prot

Q00987

Accession Number

NP_001138811.1

Cellular Locus

Nucleus | Nucleoplasm | Cytoplasm | Nucleus | Nucleolus

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide from the mid-protein of Human MDM2 (aa. 100-200)

Target

MDM2

Clonality

Polyclonal

Conjugation

ATTO 594

Tissue Specificity

Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.

Type

Polyclonal

Applications

WB | IHC

Validated Applications

IHC,ICC/IF

Field of Research

Purification

Peptide Affinity Purified

Detection Range

[object Object]

Concentration

1 mg/ml

Dilution

WB (1:1000) ; IHC (1:50) ; optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

640.91mM DMSO, 136.36 mM Ethanolamine, 126.89 mM chlorides, 9.09mM phosphates, 9.09mM NaHCO3

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

Shipping Conditions

Blue Ice or 4ºC

Storage Conditions

Conjugated antibodies should be stored according to the product label

Specificity

Detects ~50 kDa. ~50 kDa band is isoform 2 or 3.

Species

Human | Mouse | Rat

Location

Nucleus | Nucleoplasm | Cytoplasm | Nucleus | Nucleolus

Immunogen Species

Human

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