FNIP1 Antibody
Rabbit Anti-Human FNIP1 Polyclonal
Product Specifications
Background
Folliculin-interacting protein 1 (FNIP1) is a co-chaperone of HSP90 (1). It Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways and may regulate the phosphorylation of RPS6KB1 (2). FNIP1 is strongly expressed in the heart, liver placenta, muscle, nasal mucosa, salivary gland, and uvula. Elevated levels of FNIP1 have been detected in renal cell carcinoma (RCC) (3).
CAS Number
9007-83-4
Specifications
Detects ~130 kDa.
Product Name Alternative
Cancer, Cell Cycle, mTOR Pathway, Cancer, Autophagy
UNSPSC
12352203
Gene ID
96459
Swiss Prot
Q8TF40
Accession Number
NP_001008738.2
Cellular Locus
Cytoplasm
Host
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthetic peptide from the mid-protein of Human FNIP1
Target
FNIP1
Clonality
Polyclonal
Conjugation
Unconjugated
Tissue Specificity
Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.
Validated Applications
WB,ICC/IF,IHC
Purification
Peptide Affinity Purified
Concentration
1 mg/ml
Dilution
WB (1:1000); ICC/IF (1:100); IHC (1:50); optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Woodford, M. R. et al. (2016) Nature Com. 12037.
2. Baba, M. et al. (2006) Proc Natl Acad Sci U.S.A. 103(42):15552-7.
3. www.uniprot.org/uniprot/Q8TF59
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