FNIP1 Antibody: RPE

Rabbit Anti-Human FNIP1 Polyclonal

Product Specifications

Background

Folliculin-interacting protein 1 (FNIP1) is a co-chaperone of HSP90 (1). It Inhibits the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. It may be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways and may regulate the phosphorylation of RPS6KB1 (2). FNIP1 is strongly expressed in the heart, liver placenta, muscle, nasal mucosa, salivary gland, and uvula. Elevated levels of FNIP1 have been detected in renal cell carcinoma (RCC) (3).

CAS Number

9007-83-4

Specifications

Detects ~130 kDa.

Product Name Alternative

Cancer, Cell Cycle, mTOR Pathway, Cancer, Autophagy

UNSPSC

12352203

Gene ID

96459

Swiss Prot

Q8TF40

Accession Number

NP_001008738.2

Cellular Locus

Cytoplasm

Host

Rabbit

Species Reactivity

Human,Mouse,Rat

Immunogen

Synthetic peptide from the mid-protein of Human FNIP1

Target

FNIP1

Clonality

Polyclonal

Conjugation

RPE

Tissue Specificity

Strong expression is found in the heart, liver placenta, muscle, nasal mucosa, salivary gland and uvula and moderate expression in kidney and lung. Higher levels detected in clear cell renal cell carcinoma (RCC) and chromophobe RCC than in normal kidney tissue.

Validated Applications

WB,IHC,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:100); IHC (1:50); optimal dilutions for assays should be determined by the user.

Weight

0.1

Buffer

95.64mM Phosphate, 2.48mM MES and 2mM EDTA

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Woodford, M. R. et al. (2016) Nature Com. 12037. 2. Baba, M. et al. (2006) Proc Natl Acad Sci U.S.A. 103(42):15552-7. 3. www.uniprot.org/uniprot/Q8TF57