Human HMGB1 Protein, Mouse IgG2a Fc Tag, low endotoxin
High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
Product Specifications
Background
Specifications
Accession Number
P09429-1
Expression Region
Gly 2 - Glu 215
Host
HEK293
Target
HMGB1
Conjugation
Unconjugated
Tag
N-mFc (mIgG2a)
Source
Human
Stability
Endotoxin
0.1 EU per μg
Purity
95%
Format
Powder
Buffer
50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
Additives
Trehalose
Molecular Weight
51.6 kDa
Additionnal Information
Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/support/shipping-and-payments
Shipping Conditions
RT
Storage Conditions
-20°C
Package Size
500ug*2
Host or Source
HEK293
Species
Human
Protein ID
P09429-1
Preservative
Trehalose
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