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Choline Acetyltransferase Antibody

Rabbit Anti-Human Choline Acetyltransferase Polyclonal

Product Specifications

Background

Acetylcholine (ACh) is a common neurotransmitter for motoneurons, preganglionic autonomic neurons, postganglionic parasympathetic neurons, a variety of brain regions and some emerging neuron-like stem cells. The metabolism of Ach is relatively simple, involving only two enzymes: choline acetyltransferase (ChAT) for synthesis and acetylcholinesterase (AChE) for degradation. Further, acetylcholine has little function in neurons other than neurotransmission and seems to be neuron specific. It seems that only cholinergic neurons have significant amounts of ChAT making anti-choline acetyltransferase a useful specific marker. ChAT is a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease and Down syndrome (1-3).

Specifications

Predicted molecular weight at ~82.5kDa. Observed molecular weights between 68-70kDa.

Product Name Alternative

Neuroscience, Neurotransmission, Neurotransmitter Receptors, Cell Signaling, Neurodegeneration, Alzheimer's Disease

UNSPSC

12352203

Gene ID

1103

Swiss Prot

P28329

Accession Number

NP_001136401.1

Cellular Locus

Cytoplasm | Cytosol | Mitochondrion | Nucleus

Host

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide from the N-terminal to the mid-protein of human Choline O-Acetyltrasferase

Target

Choline Acetyltransferase

Clonality

Polyclonal

Conjugation

Unconjugated

Validated Applications

WB,ICC/IF

Purification

Peptide Affinity Purified

Concentration

1 mg/ml

Dilution

WB (1:1000); ICC/IF (1:100); optimal dilutions for assays should be determined by the user.

Weight

0.012

Buffer

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Precautions

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

References & Citations

1. Houser C.R., Crawford G.D., Barber R.P., Salvaterra P.M., Vaughn J.E. (1983) Brain Research. 266(1): 97-119. 2. Karson C.N., Casanova M.F., Kleinman J.E.m Griffin W.S. (1993) Am J Psychiatry. 150: 454-459. 3. Baskins D.S., et al. (1999) Arch Neurol. 56: 1121-1123.

Product MSDS

https://cdn.gentaur.com/products/400/4416133/msds/spc-706s.pdf

CAS Number

9007-83-4

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