BDNF Antibody: RPE

Brain-derived neurotrophic factor (BDNF) is a critical member of the neurotrophin family of growth factors, which also includes nerve growth factor (NGF) . Encoded by the BDNF gene, this protein is widely expressed in the central and peripheral nervous systems, where it plays a pivotal role in neuronal survival, differentiation, synaptic plasticity, and long-term memory formation. BDNF is essential for maintaining the structural and functional integrity of neurons throughout life. It supports neurogenesis and modulates synaptic transmission, making it a key regulator of brain plasticity. Altered BDNF expression has been implicated in a range of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS) . In motor neuron diseases such as ALS, BDNF has shown potential neuroprotective effects by promoting motor neuron survival and function. Its therapeutic relevance is being actively explored in clinical and preclinical models, where BDNF delivery or upregulation may help counteract progressive neuronal loss. Given its central role in neural health and disease, BDNF is a promising biomarker and therapeutic target in neurodegenerative research. Enhancing BDNF signaling could offer novel strategies for slowing disease progression and promoting neural repair in a variety of neurological conditions.

A 1:1000 dilution of SPC-703 was sufficient for detection of BDNF on 293T Rapamycin-treated lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

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